Antimicrobial studies of Allicin with Paeonol and its oxime

Samya Mairaj and F. Rehman

Department of Analytical Chemistry, Faiz-E-Aam Degree College, Meerut

Email: somyamairaj@yahoo.com

Abstract:

It has been reported that Allium Sativum contains a large number of essential metal, carbohydrate, Protein, vitamins and volatile oil and allicin is one of the active ingredients of freshly crushed garlic homogenates and has a variety of antimicrobial activities and used to prevent the heart diseases that include artherosclerosis , high cholesterol and high blood pressure. Antimicrobial activity of allicin is mainly due to S-S and S-O bond which has the ability to react with thiol containing enzyme to form S- thiolation products, the broad spectrum antimicrobial effect of allicin is due to the multiple inhibitory effects on various  thiol dependent enzymatic systems. Anticholesterol activity was tested by standard method and results shows that cholesterol level (LDL) decrease significantly, When allicin is used for 8-16 week. The antimicrobial activity of different concentration of allicin, Paeonol and its oxime were measured by determining the growth of test fungus and bacteria by dry weight increased method and by  agar  diffusion  method  against  Aspergillus  flavus,  Aspergillus  niger,  Cryptococcus  &  E.  Coli bacteria. The results indicate that oxime of paeonol has more antimicrobial properties as compare to paeonol and allicin. The activity index for different microbes has also been calculated.

Keywords: Allium sativum, Paeonol, A. I., Antimicrobial activity, Richard’s liquid medium.