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Synthesis of some novel 1-Ethyl-4-[4-(5-phenyl-3,4-dihydro-2H-pyrazol-3-yl)- phenyl]-piperazine (pyrazolines) derivatives from  3-[4-(4-Ethyl-piperazin-1-yl)- phenyl]-1-phenyl-propenone (Chalcone) derivatives and their antimicrobial activities


S. Shah N.N.1,  M.A.Baseer


1 P.G. Department of Chemistry, Yeshwant College Nanded, Maharashtra (India)

E-mail: sshahquadri@gmail.com



Heterocyclic compounds are the well known class of compounds for its biological application1-3. One of these heterocyclic compounds i.e. pyrazoline has attracted much of attention from the researchers due to possession of broad spectrum of biological applications. Pyrazolines are known to possess antmicrobial, antiinflammatory,  antimycobacterial,  antihistaminic,  acetyl  cholinesterase  inhibitor1,2, antiamoebic, antitumor, antidepressant, insecticidal and anticoagulant activities.

In present investigation, we reported here the synthesis of derivatives of 1-Ethyl-4-[4-(5-phenyl-3,4-dihydro-2H-pyrazol-3-yl)-phenyl]-piperazine (pyrazolines) from 3-[4-(4-Ethyl-piperazin-1-yl)-phenyl]-1-phenyl-propenone (chalcones) derivatives and hydrazine hydrate in basic condition using methanol as a solvent for the reaction. These synthesized compounds were established on the basis of IR, 1H NMR, Mass spectroscopic data which were further screened for their antimicrobial studies using different strains of bacteria and fungi. The synthesized compounds showed moderate to good activity.

Keywords: Chalcones, Hydrazine hydrate, Pyrazolines, Antimicrobial activities.



1.   A.Agarwal, K. Srivastava, S. K. Puri and Prem M. S. Chauhan. , Bioorganic & Medicinal Chemistry 2005; 13: 6226–6232.

2.   Ning Ma, Zhi Jin Fan, Bao Lei Wang, Yong Hong Li, Zheng Ming Li.,Chinese Chemical Letters 2008; 19: 1268–1270.


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