Synthesis and characterization of MCM-22 and their role as catalyst to synthesis 1,5-benzodiazepines

Sheikh Abdul Majid, Waheed Ahmad Khanday, Udaypal Singh Thakur, Priya Pawayia Radha Tomar

Department of Chemistry, Jiwaji University, Gwalior (M. P.), India – 474011

Email: ali.majid66@gmail.com

Abstract:

MCM-22 was synthesized by hydrothermal conditions and characterized by various techniques Viz: X-ray diffraction (XRD), FT-IR, Scanning electron microscopy (SEM),  BET Surface Analysis, Electron dispersion spectroscopy (EDX) and Thermal programmed desorption (TPD). It was then converted into H-forms by ion exchange using 1M ammonium nitrate. The above synthesized material was used as eco-friendly catalyst to synthesis 1,5-benzodiazepines derivatives .These reaction were carried out by condensation of o-phenylenediamine (OPDA) and ketones in the presence of catalytic amount of H-MCM-22 using acetonitrile as solvent at room temperature. In all the cases, the reactions are highly selective and are completed within 1-3 h.The method is applicable to both cyclic and acyclic ketones without significant differences. The reaction proceeds efficiently under ambient conditions with good to excellent yields. The catalysts were successfully recovered and reused [1-2].

Keywords: H-MCM-22, 1, 5-benzodiazepine, OPDA, Ketone

References:

1.   J.R. De Baun, F.M. Pallos, D.R. Baker, US Patent 3,978,227, 1976.

2.   J.R. De Baun, F.M. Pallos, D.R. Baker, Chem. Abstr. 86 (1977) 5498d.