Mass Spectral studies of steroidal thiazole

Azhar U. Khan^1,2*, Nazia Malik¹, Shaila Khan², Iqbal²  and M. Mushfiq¹

¹Department of Chemistry Aligarh Muslim University, Aligarh-202002, India

²Al.Falah School of Engineering and Technology Dhauj Faridabad (Haryana)

Email: azhar.u.kh@gmail.com

Abstract:

Mass spectra of some steroidal thiazole as an attempt to establish spectra structure relationship. The compounds included in the study are  2’-N-phenylamino-5α-cholest-6-eno[6,7-d] thiazole (1) 3β-acetoxy-2’-N-phenylamino-5α-cholest-6-eno[6,7-d]  thiazole and  3β-propanoyloxy 2’-phenylamino-5α-cholest  6-eno[6,7-d]  thiazole.  These compounds  are  structurally very close to  each other. It  was anticipated that they will follow similar fragmentation patterns thus offering a simple and effective method of their characterization by mass spectrometer. The mass spectrum of above compound (1) gave a prominent molecular peak at mz 58 (C₃₄H₅₀N₂S).

Keywords:  Steroidal  Ketones,  Thiazole  Steroidal  Thiazole  And  Mass  Fragmentation