KF/ alumina-catalyzed rapid and efficient synthesis of 3,5-diaryl-2,6-dicyanoanilines under solvent-free microwave conditions

Balwant S. Keshwal*, Deepika Rajguru and Shubha Jain

School of Studies in Chemistry, Vikram University, Ujjain, Madhya Pradesh, INDIA-456010

Email: bskeshwal2@gmail.com

Abstract:

A rapid and efficient synthesis of 3,5-diaryl-2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenemalonodinitriles in the presence of KF/ alumina as catalyst under microwave irradiation without solvent. Use of non-hazardous solid base as a catalyst, operational simplicity, short reaction times and excellent yields are the key advantages of the present protocol.

Keywords: 3,5-diaryl-2,6-dicyanoanilines, microwave irradiation, solvent-free, synthesis

References:

1.   Milart, P.; Wilamowski, J.; Sepiol, J. J., Tetrahedron, 1998, 54, 15643.

2.   Das, P.; Butcher, R. J.; Mukhopadhyay, C., Green Chem., 2012, 14, 1376.