A green and efficient synthesis of pyrano[3,2-c]chromenes under solvent-free conditions by grinding and their biological evaluation as antitumor agents

Deepika Rajguru¹, Balwant S. Keshwal and Shubha Jain

¹ School of Studies in Chemistry, Vikram University, Ujjain, Madhya Pradesh, INDIA-456010

Email:  deepika.rajguru23@gmail.com

Abstract:

A facile, green and efficient method has been developed for the synthesis of pyrano[3,2-c]chromenes via one-pot reaction of aromatic aldehydes, malononitrile and 4-hydroxycoumarin in the presence of ammonium acetate under solvent-free conditions using grinding method. The experimental simplicity, short reaction time, easy work-up, avoidance of organic solvents and utilization of an inexpensive and readily available catalyst make this new methodology practical and economically attractive. The antitumor  activity of  the  compounds  was  tested  against  human  breast  cancer  cell  line  MCF-7. Compounds 4i, 4j and 4l showed good cytotoxic activity comparable with standard drug Doxorubicin whereas compounds 4o and 4p exhibited potent growth inhibitory activity.

Keywords: Pyrano[3,2-c]chromene, green chemistry, griniding, solvent-free, cytotoxicity, human breast cancer

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