A study on the mixtures of cationic drugs with sodium deoxycholate

A. Srivastava and K. Ismail

Department of Chemistry North-Eastern Hill University, Shillong-793022

Email: ani_srivastava83@yahoo.co.in

Abstract:

Aggregation behavior of tetracaine hydrochloride (THC) + sodium deoxycholate (SDC) and chlorphenramine maleate (CPM) + SDC mixtures in aqueous medium has been studied using tensiometric, conductometric, spectrophotometric, dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. Synergy in critical micelle concentration (cmc) has been observed. However, positive and negative deviations in cmc from the ideality have been noticed in both the drugs at intermediate mole fraction ranges. The dependence of the cmc on the composition of the drug – surfactant mixtures has been analyzed and quantified using Clint and Rodenas equations. DLS studies suggest an increase in the hydrodynamic radius of the aggregate of the drug – surfactant systems in the mole fraction range from 0.1 to 0.5, but a decrease from 0.6 to 0.9 mole fraction. The interesting part of these systems is the formation of vesicles and sizes of these vesicles were  found  to  be  around  82  to  2048  nm.  This  observation  was  also  supported  by  the  TEM measurement.

Keywords: tetracaine hydrochloride,chlorphenramine maleate and sodium deoxycholate, tensiometric, conductometric, spectrophotometric, dynamic light scattering (DLS) and transmission electron microscopy (TEM)