A study on the mixtures of cationic drugs with sodium deoxycholate
A. Srivastava and K. Ismail
Department of Chemistry North-Eastern Hill University, Shillong-793022
Aggregation behavior of tetracaine hydrochloride (THC) + sodium deoxycholate (SDC) and chlorphenramine maleate (CPM) + SDC mixtures in aqueous medium has been studied using tensiometric, conductometric, spectrophotometric, dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. Synergy in critical micelle concentration (cmc) has been observed. However, positive and negative deviations in cmc from the ideality have been noticed in both the drugs at intermediate mole fraction ranges. The dependence of the cmc on the composition of the drug – surfactant mixtures has been analyzed and quantified using Clint and Rodenas equations. DLS studies suggest an increase in the hydrodynamic radius of the aggregate of the drug – surfactant systems in the mole fraction range from 0.1 to 0.5, but a decrease from 0.6 to 0.9 mole fraction. The interesting part of these systems is the formation of vesicles and sizes of these vesicles were found to be around 82 to 2048 nm. This observation was also supported by the TEM measurement.
Keywords: tetracaine hydrochloride,chlorphenramine maleate and sodium deoxycholate, tensiometric, conductometric, spectrophotometric, dynamic light scattering (DLS) and transmission electron microscopy (TEM)