Regenerated Cellulose-Poly (acrylamide) Hydrogel Films for Potential Wound Healing Applications: An In-Vitro Study
Dinesh Gautam, S. K. BajpaiA* Dr.Manjula Bajpai
Polymer Research Laboratory Dept. of Chemistry Govt. Model Science College,Jabalpur-(MP)482001 India
In the present work, regenerated cellulose/poly (acrylamide) films have been synthesized for wound dressing applications. The water absorbency of these films was a function of amount of crosslinker N, N’- methylene bisacrylamide, and cellulose in the feed mixture. The samples, having different compositions, showed Tensile Strength in the range of 9.98x105 to 13.40x105 N/m2. The percent elongation of the films was abnormally high in the range of 110 to 265. The water vapor transmission rate (WVTR) for various films was found to be in the range of 2.03 to 7.18 mg/cm2/h. These films were loaded with antibacterial drug Miconazole Nitrate and their release was studied in the physiological pH at 37oC. The release data was found to fit well the diffusion controlled Higuchi model. Finally the films demonstrated fair antibacterial action thus establishing their strong candidature as wound dressing materials. These hydrogels were characterized by FTIR, analysis. Finally hydrogels shows antibacterial and antifungal activity.
Keywords: Wound dressings, swelling, hydrogel, moisture permeability
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