Musa sapientum Loaded Chitosan based Films for Biomedical Application

Fehmeeda Khatoon, Mumtaz Jahan

Department of Applied Sciences & Humanities Jamia Millia Islamia, New Delhi-110025

Email: fehmeeda 58@gmail.com

Abstract:

Polyethylene Glycol (PEG), a biocompatible synthetic polymer is used for the enhancement of favourable properties of CS after blending. Biodegradable films composed of CS and PEG with various composition ratio were prepared. The chemical structure of the blend film was characterized with FTIR spectroscopy, which showed no chemical bond formation between CS and PEG but only physical interaction takes place. The DSC helps to explain the thermal stability of films. The blend of CS/PEG was cross-linked with glyoxal for increasing the water resistance property of films. The swelling  behaviour  of  cross-linked  blend  was  investigated  and  found  to  be  pH  sensitive.   In continuation of work to develop the antimicrobial activity of Musa sapientum extract against Gram-positive and Gram-negative bacteria (Bacillus subtilis, Bacillus cereus and Escherichia coli) with extract-incorporated CS∕PEG blended  ilm. The extraction was carried out in ethanol, chloro orm and water. The antimicrobial activity of the extracts evaluated using disc diffusion method and Minimum Inhibition Concentration (MIC). Ethanol extract showed an antibacterial activity against the tested microorganisms.

Keywords: Polyethylene Glycol (PEG), antibacterial activity

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