Synthesis, Characterizations, Anticancer Activities and In-silico studies of Pyrazolealdehydes Based Curcumin-I Derivatives

Imran Ali*¹, Ashanul Haque¹, Kishwar Saleem¹  and Ming Fa Hsieh²

¹Department of Chemistry, Jamia Millia Islamia New Delhi-110025, India.

²Department of Biomedical Engg., Chung Yuan Christian University, 200, Chung Li, Taiwan

Email: haque_chem@yahoo.com

Abstract:

Vilsmeier–Haack reaction was used to prepare different substituted pyrazolealdehydes, which were attached to the curcumin-I via Knoevenagel condensation. Further, the disemicarbazone derivatives of the condensates were prepared. All these compounds were characterized and purified by different spectroscopic and chromatographic techniques. The anticancer activities of the compounds on MCF-7 cell line were in the range of 59-79% (at 1.0 µg/mL).  In-silico studies indicated that pyrazolealdehydes preferred to enter minor groove, whereas Knoevenagel condensates and their corresponding disemicarbazones favored major grooves of DNA.

Keywords: Anticancer agents, Curcumin-I derivatives, In-silico Studies.