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Synthesis and biological activities of several 2-[{(4-Substituted-1- ylsulphonyl) sydnon-3-yl}]-1,3,4-thiadiazino(6,5-b)indoles


Nidhi Chaudhary1 and Hament Panwarb2


1 Department of Chemistry, Neelkanth Institute of Technology, Modipuram-250110 Meerut, U.P., India

2 Department of Chemistry, M. I. E. T., Meerut-250001, U.P., India

Email: rasayanic@gmail.com



A series of 2-[{(4-Substituted-1-ylsulphonyl)sydnon-3-yl}]-1,3,4-thiadiazino(6,5-b)indoles [4a-f] synthesised and studied for their antimicrobial activities. Structures of the synthesized substituted indoles were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N). Selected strains of microbes were used for the antibacterial and antifungal activities. Substituted sydnonyl-3-yl indoles [4a-f] explored mild to moderate biological spectrum against the used microbes. Among the all screened compounds; 4g displayed significant antimicrobial activity.


Keywords: Substituted indole, IR, NMR, 1H-NMR